Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human GSK3B
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is a negative regulator of glucose homeostasis and is involved in energy metabolism inflammation ER-stress mitochondrial dysfunction and apoptotic pathways Defects in this gene have been associated with Parkinson disease and Alzheimer disease
ABclonal Technology 488 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 647 Rabbit anti-Human CD28
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 610 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology 700 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 594 Rabbit anti-Human FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family It is selectively expressed in reactive stromal fibroblasts of epithelial cancers granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development tissue repair and epithelial carcinogenesis Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 594 Rabbit anti-Human CD307b
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology 647 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 488 Rabbit anti-Human CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily This protein is expressed by antigen-presenting cells and it is the ligand for two proteins at the cell surface of T cells CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response Alternative splicing results in several transcript variants encoding different isoforms
ABclonal Technology APC/Cyanine7 Rabbit anti- IgM
Enables several functions including antigen binding activity identical protein binding activity and immunoglobulin receptor binding activity Acts upstream of or within several processes including early endosome to late endosome transport immunoglobulin mediated immune response and positive regulation of B cell proliferation Located in external side of plasma membrane extracellular space and perinuclear region of cytoplasm Part of B cell receptor complex and immunoglobulin complex circulating Is expressed in several structures including brain hemolymphoid system and liver Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus Human ortholog(s) of this gene implicated in agammaglobulinemia Orthologous to human IGHM (immunoglobulin heavy constant mu)
ABclonal Technology PE Rabbit anti-Human Ki67 mAb
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology PE Rabbit anti-Human TNF-a mAb
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine